In molecular biology, T-cell leukemia/lymphoma 6 (non-protein coding), also known as TCL6 is a long non-coding RNA. It is expressed in T-cell leukemia with a t(14;14)(q11;q32.1) chromosome translocation in humans and in a mouse model. It is not expressed in normal T-cells.[1][2] It may be involved in leukemogenesis.[2]
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References edit
- ^ Hallas C, Pekarsky Y, Itoyama T, Varnum J, Bichi R, Rothstein JL, et al. (1999). "Genomic analysis of human and mouse TCL1 loci reveals a complex of tightly clustered genes". Proc Natl Acad Sci U S A. 96 (25): 14418–14423. Bibcode:1999PNAS...9614418H. doi:10.1073/pnas.96.25.14418. PMC 24451. PMID 10588720.
- ^ a b Saitou M, Sugimoto J, Hatakeyama T, Russo G, Isobe M (2000). "Identification of the TCL6 genes within the breakpoint cluster region on chromosome 14q32 in T-cell leukemia". Oncogene. 19 (23): 2796–2802. doi:10.1038/sj.onc.1203604. PMID 10851082.
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