TCEAL1

Transcription elongation factor A protein-like 1 is a protein that in humans is encoded by the TCEAL1 gene.

TCEAL1
Identifiers
Aliases	TCEAL1, SIIR, WEX9, p21, pp21, transcription elongation factor A like 1
External IDs	OMIM: 300237 MGI: 2385317 HomoloGene: 3510 GeneCards: TCEAL1
Gene location (Human) Chr. X chromosome (human) Band Xq22.2 Start 103,628,704 bp End 103,630,953 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F1 Start 135,608,731 bp End 135,612,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left uterine tube gastric mucosa right coronary artery canal of the cervix thoracic aorta ascending aorta left coronary artery popliteal artery myometrium seminal vesicula Top expressed in dorsomedial hypothalamic nucleus facial motor nucleus mammillary body arcuate nucleus paraventricular nucleus of hypothalamus median eminence ventromedial nucleus Region I of hippocampus proper barrel cortex lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity WW domain binding Cellular component nucleus nucleoplasm Biological process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9338 237052 Ensembl ENSG00000172465 ENSMUSG00000049536 UniProt Q15170 Q921P9 RefSeq (mRNA) NM_004780 NM_001006639 NM_001006640 NM_146236 NM_001356367 RefSeq (protein) NP_001006640 NP_001006641 NP_004771 NP_666348 NP_001343296 Location (UCSC) Chr X: 103.63 – 103.63 Mb Chr X: 135.61 – 135.61 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform.

Further reading

• Yeh CH, Zong WX, Shatkin AJ (1995). "The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression". J. Biol. Chem. 270 (43): 25313–5. doi:10.1074/jbc.270.44.26558. PMID 7592688.
• Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ (1999). "Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR". Genomics. 56 (2): 217–20. doi:10.1006/geno.1998.5705. PMID 10051408.
• van der Kuip H, Carius B, Haque SJ, et al. (1999). "The DNA-binding subunit p140 of replication factor C is upregulated in cycling cells and associates with G1 phase cell cycle regulatory proteins". J. Mol. Med. 77 (4): 386–92. doi:10.1007/s001090050365. PMID 10353443. S2CID 22183443.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Makino H, Tajiri T, Miyashita M, et al. (2005). "Differential expression of TCEAL1 in esophageal cancers by custom cDNA microarray analysis". Diseases of the Esophagus. 18 (1): 37–40. doi:10.1111/j.1442-2050.2005.00432.x. PMID 15773840.
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.