TAGLN2

Transgelin-2 is a protein that in humans is encoded by the TAGLN2 gene.

TAGLN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WYM
Identifiers
Aliases	TAGLN2, HA1756, transgelin 2
External IDs	OMIM: 604634; MGI: 1312985; HomoloGene: 20789; GeneCards: TAGLN2; OMA:TAGLN2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.2 Start 159,918,107 bp End 159,925,507 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H3|1 79.89 cM Start 172,327,614 bp End 172,334,947 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung right lung monocyte granulocyte islet of Langerhans ventricular zone skin of abdomen mucosa of transverse colon minor salivary glands gallbladder Top expressed in pyloric antrum epithelium of stomach mucous cell of stomach lip tail of embryo right lung yolk sac right lung lobe esophagus left lung More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding cadherin binding Cellular component vesicle extracellular exosome extracellular region cytosol Biological process epithelial cell differentiation platelet degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8407 21346 Ensembl ENSG00000158710 ENSMUSG00000026547 UniProt P37802 Q9WVA4 RefSeq (mRNA) NM_003564 NM_001277223 NM_001277224 NM_178598 RefSeq (protein) NP_001264152 NP_001264153 NP_003555 NP_848713 Location (UCSC) Chr 1: 159.92 – 159.93 Mb Chr 1: 172.33 – 172.33 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a homolog of the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The function of this protein has not yet been determined.

Further reading

• Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.