St. Joe, Illinois is a small unincorporated community in the historic New Design Precinct of Monroe County, Illinois, United States. It is located along the historic road from Kaskaskia to St. Louis, between Renault and Burksville.

St. Joe, Illinois
St. Joe is located in Illinois
St. Joe
St. Joe
St. Joe is located in the United States
St. Joe
St. Joe
Coordinates: 38°13′58″N 90°09′13″W / 38.23278°N 90.15361°W / 38.23278; -90.15361
CountryUnited States
StateIllinois
CountyMonroe
Precinct23
Elevation
705 ft (215 m)
Time zoneUTC-6 (CST)
 • Summer (DST)UTC-5 (CDT)
Postal code
62298
Area code618