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Spina vestibuli, or vestibular spine, is a bony structure, in anatomical terms a 'mesenchymal condensation', which extends from the mediastinum of the heart and covers the leading edge of the primary atrial septum; its origin is outside of the heart. Below the opening of the orifice of the coronary sinus they fuse to form a triangular thickening — the spina vestibuli. It is believed to play a formative role in atrial septation, which is how the common atrium of the heart divides into two during gestation. Its lack of development is thought to contribute to the morphogenesis of atrioventricular septal defect (AVSD) in Down syndrome.[1]
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References edit
- ^ Blom, Nico A.; Ottenkamp, Jaap; Wenink, Arnold G. C.; Gittenberger-de Groot, Adriana C. (2003-01-15). "Deficiency of the vestibular spine in atrioventricular septal defects in human fetuses with down syndrome". The American Journal of Cardiology. 91 (2): 180–184. doi:10.1016/s0002-9149(02)03106-5. ISSN 0002-9149. PMID 12521631.
This article incorporates text in the public domain from page 510 of the 20th edition of Gray's Anatomy (1918)
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