Santísima Trinidad was the name of several Spanish ships:
- Spanish ship Santísima Trinidad (1751), the largest of the Manila galleons
- Spanish ship Nuestra Señora de la Santísima Trinidad, a first-rate ship of the line officially named Santísima Trinidad in 1768; launched in 1769; captured at the Battle of Trafalgar, but later sank in a storm
This article includes a list of ships with the same or similar names. If an internal link for a specific ship led you here, you may wish to change the link to point directly to the intended ship article, if one exists.