Southern Expressway may refer to:
- Southern Expressway, Adelaide, South Australia
- E01 expressway (Sri Lanka)
- A portion of U.S. Route 219 in New York
- A portion of Interstate 376 near Pittsburgh
- Southern Expressway (England), a road in Runcorn, Cheshire and part of the A533 road.
This disambiguation page lists articles about roads and streets with the same name.
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