In molecular biology, snoRNA SNORD90 (HBII-295) is a non-coding RNA that belongs to the family of C/D snoRNAs. Initially described as HBII-295[1] this RNA has now been called SNORD70 by the HUGO Gene Nomenclature Committee. It is the human orthologue of the mouse MBII-295 and has no identified RNA target.[2] This RNA is expressed from an intron of the MNAB/OR1K1 gene.
| Small nucleolar RNA SNORD90 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORD90 | |
| Identifiers | |
| Symbol | SNORD90 |
| Alt. Symbols | snoHBII-295 |
| Rfam | RF00579 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; C/D-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000593 |
| PDB structures | PDBe |
There is evidence that SNORD90 is involved in guiding N6-methyladenosine (m6A) modifications onto target RNA transcripts.[3] Specifically, SNORD90 has been shown to increase m6A levels on neuregulin 3 (NRG3) leading to its down-regulation through recognition by YTHDF2.[3]
References edit
- ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
- ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
- ^ a b Lin, Rixing; Kos, Aron; Lopez, Juan Pablo; Dine, Julien; Fiori, Laura M; Yang, Jennie; Ben-Efraim, Yair; Aouabed, Zahia; Ibrahim, Pascal; Mitsuhashi, Haruka; Wong, Tak Pan; Ibrahim, El Cherif; Belzung, Catherine; Blier, Pierre; Farzan, Faranak (2023-07-11). West, Anne E; Wong, Ma-Li (eds.). "SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants". eLife. 12: e85316. doi:10.7554/eLife.85316. ISSN 2050-084X. PMC 10335830. PMID 37432876.
External links edit
- Page for Small nucleolar RNA SNORD90 at Rfam
- Entry for HBII-295 at snoRNABase
- HGNC database entry[permanent dead link]
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