Small nuclear ribonucleoprotein polypeptide E

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.

SNRPE
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR
Identifiers
Aliases	SNRPE, B-raf, HYPT11, SME, Sm-E, Small nuclear ribonucleoprotein polypeptide E, snRNP-E
External IDs	OMIM: 128260; MGI: 3650419; HomoloGene: 136765; GeneCards: SNRPE; OMA:SNRPE - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 203,861,599 bp End 203,871,152 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence ventricular zone left ovary right ovary olfactory zone of nasal mucosa body of pancreas canal of the cervix ectocervix body of uterus mucosa of transverse colon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding Cellular component cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U12-type spliceosomal complex nucleoplasm methylosome U7 snRNP small nuclear ribonucleoprotein complex pICln-Sm protein complex telomerase holoenzyme complex spliceosomal complex U4 snRNP nucleus U5 snRNP U2 snRNP U4/U6 x U5 tri-snRNP complex precatalytic spliceosome U1 snRNP U2-type catalytic step 2 spliceosome U2-type precatalytic spliceosome Biological process hair cycle mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly histone mRNA metabolic process import into nucleus RNA splicing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6635 102632439 Ensembl ENSG00000182004 n/a UniProt P62304 n/a RefSeq (mRNA) NM_001304464 NM_003094 NM_001328637 NM_001328638 n/a RefSeq (protein) NP_001291393 NP_001315566 NP_001315567 NP_003085 n/a Location (UCSC) Chr 1: 203.86 – 203.87 Mb n/a PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20 and Small nuclear ribonucleoprotein polypeptide F.

Further reading

• Sauterer RA, Goyal A, Zieve GW (January 1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts". The Journal of Biological Chemistry. 265 (2): 1048–58. doi:10.1016/S0021-9258(19)40157-9. PMID 1688550.
• Stanford DR, Rohleder A, Neiswanger K, Wieben ED (July 1987). "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene". The Journal of Biological Chemistry. 262 (21): 9931–4. doi:10.1016/S0021-9258(18)61052-X. PMID 2440864.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (April 1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles". The Journal of Biological Chemistry. 264 (10): 5776–83. doi:10.1016/S0021-9258(18)83617-1. PMID 2522439.
• Stanford DR, Perry CA, Holicky EL, Rohleder AM, Wieben ED (November 1988). "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins". The Journal of Biological Chemistry. 263 (33): 17772–9. doi:10.1016/S0021-9258(19)77902-2. PMID 2972723.
• Stanford DR, Kehl M, Perry CA, Holicky EL, Harvey SE, Rohleder AM, Rehder K, Luhrmann R, Wieben ED (November 1988). "The complete primary structure of the human snRNP E protein". Nucleic Acids Research. 16 (22): 10593–605. doi:10.1093/nar/16.22.10593. PMC 338926. PMID 2974536.
• Woppmann A, Rinke J, Lührmann R (December 1988). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ". Nucleic Acids Research. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
• Kamiyama T, Aoki N, Yuasa Y (March 1993). "B-raf oncogene: activation by rearrangements and assignment to human chromosome 7". Japanese Journal of Cancer Research. 84 (3): 250–6. doi:10.1111/j.1349-7006.1993.tb02864.x. PMC 5919149. PMID 8098025.
• Plessel G, Lührmann R, Kastner B (January 1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". Journal of Molecular Biology. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Liu Q, Fischer U, Wang F, Dreyfuss G (September 1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Experimental Cell Research. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Kambach C, Walke S, Young R, Avis JM, de la Fortelle E, Raker VA, Lührmann R, Li J, Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". The Journal of Cell Biology. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (March 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". The Journal of Cell Biology. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (January 2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". The EMBO Journal. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Gubitz AK, Mourelatos Z, Abel L, Rappsilber J, Mann M, Dreyfuss G (February 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". The Journal of Biological Chemistry. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (March 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Friesen WJ, Wyce A, Paushkin S, Abel L, Rappsilber J, Mann M, Dreyfuss G (March 2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". The Journal of Biological Chemistry. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.