Small nuclear ribonucleoprotein D2

Article
Talk

Small nuclear ribonucleoprotein Sm D2 is a protein that in humans is encoded by the SNRPD2 gene.^[5]^[6]^[7] It belongs to the small nuclear ribonucleoprotein core protein family, and is required for pre-mRNA splicing and small nuclear ribonucleoprotein biogenesis. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.^[7]

SNRPD2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1B34, 3CW1, 3PGW, 3S6N, 4F7U, 4PJO, 4V98, 4WZJ, 3JCR

Identifiers

SNRPD2, SMD2, SNRPD1, Sm-D2, Small nuclear ribonucleoprotein D2, small nuclear ribonucleoprotein D2 polypeptide

External IDs

OMIM: 601061; MGI: 98345; HomoloGene: 3381; GeneCards: SNRPD2; OMA:SNRPD2 - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.32	Start	45,687,460 bp^[1]
Band	19q13.32	End	45,692,569 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 A3	Start	18,883,647 bp^[2]
Band	7\|7 A3	End	18,887,467 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

beta cell

embryo

corpus epididymis

oral cavity

left ovary

ganglionic eminence

tail of epididymis

caput epididymis

superficial temporal artery

vulva

Top expressed in

yolk sac

synovial joint

urinary bladder

ankle joint

embryo

ventricular zone

embryo

lens

epiblast

ganglionic eminence

More reference expression data

n/a

Gene ontology
Molecular function	protein binding RNA binding U1 snRNP binding
Cellular component	cytoplasm SMN-Sm protein complex cytosol catalytic step 2 spliceosome U4/U6 x U5 tri-snRNP complex U5 snRNP U12-type spliceosomal complex U2 snRNP nucleoplasm methylosome precatalytic spliceosome small nuclear ribonucleoprotein complex pICln-Sm protein complex spliceosomal complex U4 snRNP extracellular exosome nucleus U1 snRNP U2-type precatalytic spliceosome U2-type catalytic step 2 spliceosome
Biological process	mRNA splicing, via spliceosome mRNA processing spliceosomal snRNP assembly spliceosomal complex assembly RNA splicing import into nucleus
Sources:Amigo / QuickGO

Species

Human

Mouse


6633


107686


ENSG00000125743


ENSMUSG00000040824


P62316


P62317

RefSeq (mRNA)


NM_004597 NM_177542 NM_001369751 NM_001369752 NM_001384647


NM_026943

RefSeq (protein)


NP_004588 NP_808210 NP_001356680 NP_001356681


NP_081219

Location (UCSC)

Chr 19: 45.69 – 45.69 Mb

Chr 7: 18.88 – 18.89 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Interactions

Small nuclear ribonucleoprotein D2 has been shown to interact with DDX20,^[8] Small nuclear ribonucleoprotein D1,^[9]^[10] Small nuclear ribonucleoprotein polypeptide F,^[9] CDC5L^[11] and SMN1.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125743 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040824 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lehmeier T, Raker V, Hermann H, Luhrmann R (January 1995). "cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a direct D1-D2 interaction". Proc Natl Acad Sci U S A. 91 (25): 12317–21. Bibcode:1994PNAS...9112317L. doi:10.1073/pnas.91.25.12317. PMC 45428. PMID 7527560.
^ Lehmeier T, Foulaki K, Luhrmann R (January 1991). "Evidence for three distinct D proteins, which react differentially with anti-Sm autoantibodies, in the cores of the major snRNPs U1, U2, U4/U6 and U5". Nucleic Acids Res. 18 (22): 6475–84. doi:10.1093/nar/18.22.6475. PMC 332598. PMID 1701240.
^ ^a ^b "Entrez Gene: SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa".
^ Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6). UNITED STATES: 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
^ ^a ^b Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1). UNITED STATES: 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.
^ Kambach, C; Walke S; Young R; Avis J M; de la Fortelle E; Raker V A; Lührmann R; Li J; Nagai K (February 1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3). UNITED STATES: 375–87. doi:10.1016/S0092-8674(00)80550-4. ISSN 0092-8674. PMID 10025403. S2CID 17379935.
^ Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23). ENGLAND: 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.
^ Meister, G; Bühler D; Laggerbauer B; Zobawa M; Lottspeich F; Fischer U (August 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13). ENGLAND: 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426.

Further reading

Rokeach LA, Haselby JA, Hoch SO (1988). "Molecular cloning of a cDNA encoding the human Sm-D autoantigen". Proc. Natl. Acad. Sci. U.S.A. 85 (13): 4832–6. Bibcode:1988PNAS...85.4832R. doi:10.1073/pnas.85.13.4832. PMC 280530. PMID 3260384.
Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins". Cell. 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129. S2CID 10855404.
Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs". Cell. 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403. S2CID 17379935.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
Meister G, Bühler D, Laggerbauer B, et al. (2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. PMID 10942426.
Ajuh P, Kuster B, Panov K, et al. (2001). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. PMC 305846. PMID 11101529.
Selenko P, Sprangers R, Stier G, et al. (2001). "SMN tudor domain structure and its interaction with the Sm proteins". Nat. Struct. Biol. 8 (1): 27–31. doi:10.1038/83014. PMID 11135666. S2CID 27071310.
Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
Baccon J, Pellizzoni L, Rappsilber J, et al. (2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". J. Biol. Chem. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Blagoev B, Kratchmarova I, Ong SE, et al. (2003). "A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling". Nat. Biotechnol. 21 (3): 315–8. doi:10.1038/nbt790. PMID 12577067. S2CID 26838266.

Retrieved from "https://en.wikipedia.org/w/index.php?title=Small_nuclear_ribonucleoprotein_D2&oldid=1083113014"