Slx1 structure-specific endonuclease subunit homolog b (s. cerevisiae)

SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) is a protein in humans that is encoded by the SLX1B gene. [5]

SLX1B
Identifiers
AliasesSLX1B, GIYD2, Slx1 structure-specific endonuclease subunit homolog b, SLX1 homolog B, structure-specific endonuclease subunit
External IDsOMIM: 615823; MGI: 1915220; HomoloGene: 11434; GeneCards: SLX1B; OMA:SLX1B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_178044
NM_024044
NM_001400286
NM_001400287

NM_029420

RefSeq (protein)

NP_001014999
NP_001015000

NP_083696

Location (UCSC)Chr 16: 29.45 – 29.46 MbChr 7: 126.29 – 126.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181625Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059772Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)". Retrieved 2013-05-19.

Further reading

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