Skyline High School can refer to:
- Skyline High School (Alabama), in Scottsboro
- Skyline High School (Arizona), in Mesa
- Skyline High School (Lemon Grove, California)
- Skyline High School (Oakland, California)
- Skyline High School (Colorado), in Longmont
- Skyline High School (Idaho), in Idaho Falls
- Skyline High School (Kansas), in Pratt
- Skyline High School (Michigan), in Ann Arbor
- Skyline High School (Missouri), in Urbana
- Skyline High School (Montana), in Great Falls
- Skyline High School (Oregon), in Oakland
- Skyline High School (Dallas)
- Skyline High School (Utah), in Millcreek
- Skyline High School (Virginia), in Front Royal
- Skyline High School (Washington), in Sammamish
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