In molecular biology, Six3OS1 is a long non-coding RNA. It was originally identified in the murine embryonic and postnatal retina.[1] It is located in the distal promoter region of the gene encoding Six3, a homeodomain transcription factor. It regulates the activity of Six3 in the developing mouse retina, by binding to transcriptional co-regulators of Six3 and to histone modification enzymes and acting as a transcriptional scaffold.[2]
References edit
- ^ Alfano G, Vitiello C, Caccioppoli C, Caramico T, Carola A, Szego MJ, et al. (2005). "Natural antisense transcripts associated with genes involved in eye development". Hum Mol Genet. 14 (7): 913–923. doi:10.1093/hmg/ddi084. PMID 15703187.
- ^ Rapicavoli NA, Poth EM, Zhu H, Blackshaw S (2011). "The long noncoding RNA Six3OS acts in trans to regulate retinal development by modulating Six3 activity". Neural Dev. 6: 32. doi:10.1186/1749-8104-6-32. PMC 3191369. PMID 21936910.
Further reading edit
- Geng X, Lavado A, Lagutin OV, Liu W, Oliver G (2007). "Expression of Six3 Opposite Strand (Six3OS) during mouse embryonic development". Gene Expr Patterns. 7 (3): 252–257. doi:10.1016/j.modgep.2006.09.007. PMC 1986792. PMID 17084678.
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