Shugoshin 2 (Shugoshin-2), also known as Shugoshin-like 2, is a protein which in humans is encoded by the SGO2 gene.[5][6][7]

SGO2
Identifiers
AliasesSGO2, TRIPIN, SGOL2, shugoshin 2
External IDsOMIM: 612425; MGI: 1098767; HomoloGene: 51867; GeneCards: SGO2; OMA:SGO2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001160033
NM_001160046
NM_152524

NM_001177867
NM_199007

RefSeq (protein)

NP_001153505
NP_001153518
NP_689737

NP_001171338
NP_950172

Location (UCSC)Chr 2: 200.51 – 200.58 MbChr 1: 58.04 – 58.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Shugoshin-2 is one of the two mammalian orthologs of the Shugoshin/Mei-S322 family of proteins that regulate sister chromatid cohesion by protecting the integrity of a multiprotein complex named cohesin.[8] This protective system is essential for faithful chromosome segregation during mitosis and meiosis, which is the physical basis of Mendelian inheritance.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163535Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026039Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "UniProt". www.uniprot.org. Retrieved 6 November 2022.
  6. ^ "Entrez Gene: SGOL2 shugoshin-like 2".
  7. ^ Kitajima TS; Kawashima SA; Watanabe Y (February 2004). "The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis". Nature. 427 (6974): 510–7. Bibcode:2004Natur.427..510K. doi:10.1038/nature02312. PMID 14730319. S2CID 4400426.
  8. ^ Kitajima TS; Sakuno T; Ishiguro K; Iemura S; Natsume T; Kawashima SA; Watanabe Y (May 2006). "Shugoshin collaborates with protein phosphatase 2A to protect cohesin". Nature. 441 (7089): 46–52. Bibcode:2006Natur.441...46K. doi:10.1038/nature04663. PMID 16541025. S2CID 4425074.

Further reading

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