Shifrin, Shiffrin and Schifrin (Yiddish: שיפרין, Russian: Шифрин) is a matronymic Jewish surname of Yiddish origin. Notable people with the surname include:
- Avraham Shifrin, Soviet-born human rights activist, Zionist, author, lawyer, and Israeli politician
- David Shifrin, American classical clarinetist
- Eduard Shifrin, Ukraine-born billionaire
- Efim Shifrin, Russian actor and comedian
- Eleonora Shifrin, Soviet-born Israeli politician
- Karin Shifrin, Israeli opera singer
- Lalo Schifrin, Argentine pianist and composer
- Mikaela Shiffrin, American alpine skier
- Peter Schifrin, American Olympic fencer and sculptor
- Richard Shiffrin, American psychologist
- Seana Shiffrin, American philosopher
- Seymour Shifrin, American composer