Setastine (Loderix) is an antihistamine used to treat allergies and rhinitis.[1][2]
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| Formula | C22H28ClNO |
| Molar mass | 357.92 g·mol−1 |
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Pharmacology
editPharmacodynamics
editSetastine acts as a highly selective H1 receptor antagonist.[3] It has no anticholinergic, antiadrenergic, or antiserotonergic effects.
Pharmacokinetics
editSetastine penetrates the blood-brain-barrier poorly so it is only mildly sedating compared to related molecules like diphenhydramine.[3]
See also
editReferences
edit- ^ Lantos A, Tóth A, Zsiray M (1991). "Loderix (setastine) tablets in the treatment of allergic rhinoconjunctivitis". Therapia Hungarica. 39 (1): 22–24. PMID 1677500.
- ^ Hirschberg A, Ribári O, Krasznai M (1989). "Results obtained with Loderix tablet in chronic rhinitis patients". Therapia Hungarica. 37 (4): 202–204. PMID 2576575.
- ^ a b Porszász J, Varga F, Porszász KG, Szolscányi J, Barthó L, Petöcz L, Kápolnai L (December 1990). "Pharmacology of the new H1-receptor antagonist setastine hydrochloride". Arzneimittel-Forschung. 40 (12): 1340–1345. PMID 1982751.
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