Senator Middleton may refer to:
- Andrew C. Middleton (1824–1909), New York State Senate
- Clyde Middleton (1928–2019), Kentucky State Senate
- Henry Middleton (governor) (1770–1846), South Carolina State Senate
- Henry Middleton (1717–1784), South Carolina State Senate
- Thomas M. Middleton (born 1945), Maryland State Senate
This disambiguation page lists articles associated with the title Senator Middleton.
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