Semaphorin 3E is a protein that in humans is encoded by the SEMA3E gene. [4]

SEMA3E
Identifiers
AliasesSEMA3E, M-SEMAH, M-SemaK, SEMAH, coll-5, semaphorin 3E
External IDsOMIM: 608166; MGI: 1340034; HomoloGene: 8247; GeneCards: SEMA3E; OMA:SEMA3E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001178129
NM_012431

NM_011348

RefSeq (protein)

NP_001171600
NP_036563

NP_035478

Location (UCSC)n/aChr 5: 14.08 – 14.31 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Semaphorin are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins.

This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010].

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000063531Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Entrez Gene: Semaphorin 3E". Retrieved 2018-04-26.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.