Sean McLaughlin may refer to:
- Sean McLaughlin (meteorologist), American television meteorologist
- Sean McLaughlin (record producer), American record producer
- Sean J. McLaughlin (born 1955), United States federal judge
- Jacksepticeye (Seán W. McLoughlin, born 1990), Irish YouTuber
- Seán McLoughlin (hurler) (born 1935), Irish hurler