Scott A. Small is an American neurologist and neuroscientist known for his work in Alzheimer's disease and normal cognitive aging.[1] His research focuses on the hippocampus, a circuit in the brain targeted by Alzheimer's disease, aging, and schizophrenia. Small is the Director of the Alzheimer's Disease Research Center at Columbia University, where he is the Boris and Rose Katz Professor of Neurology. He is also appointed in Radiology and in Psychiatry, where he directs the Schizophrenia Research program.
Scott A. Small | |
|---|---|
 | |
| Alma mater | New York University (BA) Columbia University (MD) |
| Scientific career | |
| Fields | Neurobiology of Disease |
| Institutions | Columbia University |
| Doctoral advisor | Eric Kandel |
In an interview with Mike Pesca, he mentioned that he served in the Israel Defense Forces during the 1982 Lebanon War.[2]
Work edit
Small has developed high-resolution functional MRI applications that can pinpoint the areas of the hippocampus most affected by aging and disease.[3] His lab uses this ‘anatomical biology’ approach of isolating pathogenic mechanisms to identify potential causes of these disorders and inform on drug discovery and development.[4][5][6][7] To date, these mechanistic insights have led to the testing of therapeutic interventions for three hippocampal-based conditions: retromer-enhancers for Alzheimer's disease;[8][9] dietary flavanols for cognitive aging;[10] and glutamate-reducers for schizophrenia.[7]
Small has authored more than 140 papers and is an inventor of 10 patents.[1] He is the author of the 2021 book, Forgetting: The Benefits of Not Remembering, published by Crown/Penguin Random House (ISBN 978-0-593-13619-5).
References edit
- ^ a b "Scott A. Small". scholar.google.com. Retrieved 2021-03-05.
- ^ Mike Pesca (July 22, 2022). "Thot Thoughts interview with Scott Small".
- ^ Small, Scott A.; Schobel, Scott A.; Buxton, Richard B.; Witter, Menno P.; Barnes, Carol A. (October 2011). "A pathophysiological framework of hippocampal dysfunction in ageing and disease". Nature Reviews Neuroscience. 12 (10): 585–601. doi:10.1038/nrn3085. ISSN 1471-0048. PMC 3312472. PMID 21897434.
- ^ Small, Scott A. (2014-10-01). "Isolating pathogenic mechanisms embedded within the hippocampal circuit through regional vulnerability". Neuron. 84 (1): 32–39. doi:10.1016/j.neuron.2014.08.030. ISSN 1097-4199. PMC 4185396. PMID 25277453.
- ^ Small, Scott A.; Petsko, Gregory A. (March 2015). "Retromer in Alzheimer disease, Parkinson disease and other neurological disorders". Nature Reviews. Neuroscience. 16 (3): 126–132. doi:10.1038/nrn3896. ISSN 1471-0048. PMID 25669742. S2CID 5166260.
- ^ Brickman, Adam M.; Khan, Usman A.; Provenzano, Frank A.; Yeung, Lok-Kin; Suzuki, Wendy; Schroeter, Hagen; Wall, Melanie; Sloan, Richard P.; Small, Scott A. (December 2014). "Enhancing dentate gyrus function with dietary flavanols improves cognition in older adults". Nature Neuroscience. 17 (12): 1798–1803. doi:10.1038/nn.3850. ISSN 1546-1726. PMC 4940121. PMID 25344629.
- ^ a b Schobel, Scott A.; Chaudhury, Nashid H.; Khan, Usman A.; Paniagua, Beatriz; Styner, Martin A.; Asllani, Iris; Inbar, Benjamin P.; Corcoran, Cheryl M.; Lieberman, Jeffrey A.; Moore, Holly; Small, Scott A. (2013-04-10). "Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver". Neuron. 78 (1): 81–93. doi:10.1016/j.neuron.2013.02.011. ISSN 1097-4199. PMC 3966570. PMID 23583108.
- ^ Mecozzi, Vincent J.; Berman, Diego E.; Simoes, Sabrina; Vetanovetz, Chris; Awal, Mehraj R.; Patel, Vivek M.; Schneider, Remy T.; Petsko, Gregory A.; Ringe, Dagmar; Small, Scott A. (June 2014). "Pharmacological chaperones stabilize retromer to limit APP processing". Nature Chemical Biology. 10 (6): 443–449. doi:10.1038/nchembio.1508. ISSN 1552-4469. PMC 4076047. PMID 24747528.
- ^ Small, Scott A.; Petsko, Gregory A. (2020-12-02). "Endosomal recycling reconciles the Alzheimer's disease paradox". Science Translational Medicine. 12 (572): eabb1717. doi:10.1126/scitranslmed.abb1717. ISSN 1946-6234. PMC 8025181. PMID 33268506. S2CID 227249225.
- ^ Sloan, Richard P.; Wall, Melanie; Yeung, Lok-Kin; Feng, Tianshu; Feng, Xinyang; Provenzano, Frank; Schroeter, Hagen; Lauriola, Vincenzo; Brickman, Adam M.; Small, Scott A. (2021-02-15). "Insights into the role of diet and dietary flavanols in cognitive aging: results of a randomized controlled trial". Scientific Reports. 11 (1): 3837. doi:10.1038/s41598-021-83370-2. ISSN 2045-2322. PMC 7884710. PMID 33589674.