Sclareol cyclase (EC 3.1.7.4, geranylgeranyl pyrophosphate:sclareol cyclase, geranylgeranyl pyrophosphate-sclareol cyclase, GGPP:sclareol cyclase) is an enzyme with systematic name geranylgeranyl-diphosphate diphosphohydrolase (sclareol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
| Sclareol cyclase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.7.4 | ||||||||
| CAS no. | 146838-18-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- geranylgeranyl diphosphate + 2 H2O sclareol + diphosphate
This enzyme requires Mg2+ or Mn2+ for activity.
References
edit- ^ Banthorpe DV, Brown JT, Morris GS (1992). "Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material". Phytochemistry. 31 (10): 3391–3395. doi:10.1016/0031-9422(92)83692-R.
- ^ Dimas K, Hatziantoniou S, Tseleni S, Khan H, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P, Demetzos C (April 2007). "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice". Apoptosis. 12 (4): 685–94. doi:10.1007/s10495-006-0026-8. PMID 17260186.
- ^ Guo Z, Wagner GJ (1995). "Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa". Planta. 197 (4): 627–632. doi:10.1007/BF00191570.
External links
edit- Sclareol+cyclase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
