Sclareol cyclase (EC 3.1.7.4, geranylgeranyl pyrophosphate:sclareol cyclase, geranylgeranyl pyrophosphate-sclareol cyclase, GGPP:sclareol cyclase) is an enzyme with systematic name geranylgeranyl-diphosphate diphosphohydrolase (sclareol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

Sclareol cyclase
Identifiers
EC no.3.1.7.4
CAS no.146838-18-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins
geranylgeranyl diphosphate + 2 H2O sclareol + diphosphate

This enzyme requires Mg2+ or Mn2+ for activity.

References

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  1. ^ Banthorpe DV, Brown JT, Morris GS (1992). "Partial purification of farnesyl pyrophosphate:drimenol cyclase and geranylgerany pyrophosphate:sclareol cyclase, using cell culture as a source of material". Phytochemistry. 31 (10): 3391–3395. doi:10.1016/0031-9422(92)83692-R.
  2. ^ Dimas K, Hatziantoniou S, Tseleni S, Khan H, Georgopoulos A, Alevizopoulos K, Wyche JH, Pantazis P, Demetzos C (April 2007). "Sclareol induces apoptosis in human HCT116 colon cancer cells in vitro and suppression of HCT116 tumor growth in immunodeficient mice". Apoptosis. 12 (4): 685–94. doi:10.1007/s10495-006-0026-8. PMID 17260186.
  3. ^ Guo Z, Wagner GJ (1995). "Biosynthesis of labdenediol and sclareol in cell-free extracts from trichomes of Nicotiana glutinosa". Planta. 197 (4): 627–632. doi:10.1007/BF00191570.
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