Santo Tomás District may refer to:
- Peru:
- Santo Tomás District, Luya, in Luya province, Amazonas region
- Santo Tomás District, Cutervo, in Cutervo province, Cajamarca region
- Santo Tomás District, Chumbivilcas, in Chumbivilcas province, Cusco region
- Santo Tomás de Pata District, in Angaraes province, Huancavelica region
- Costa Rica:
- Santo Tomás District, Santo Domingo, in Santo Domingo canton, Heredia province