Samuel Weiss may refer to:
- Samuel Weiss (neurobiologist) (born 1955), Canadian neurobiologist
- Samuel A. Weiss (1902–1977), American politician and NFL deputy commissioner
- Samuel Weiss (mobster) (c. 1904–?), New York mobster
- Sam Weiss, a character from the TV series Fringe
This disambiguation page lists articles about people with the same name.
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