Synaptogyrin-1 is a protein that in humans is encoded by the SYNGR1 gene.[5][6][7]

SYNGR1
Identifiers
AliasesSYNGR1, synaptogyrin 1
External IDsOMIM: 603925; MGI: 1328323; HomoloGene: 3456; GeneCards: SYNGR1; OMA:SYNGR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145738
NM_004711
NM_145731

NM_009303
NM_207708

RefSeq (protein)

NP_004702
NP_663783
NP_663791

NP_033329
NP_997591

Location (UCSC)Chr 22: 39.35 – 39.39 MbChr 15: 79.98 – 80 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified.[7]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100321Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022415Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kedra D, Pan HQ, Seroussi E, Fransson I, Guilbaud C, Collins JE, Dunham I, Blennow E, Roe BA, Piehl F, Dumanski JP (Oct 1998). "Characterization of the human synaptogyrin gene family". Hum Genet. 103 (2): 131–41. doi:10.1007/s004390050795. PMID 9760194. S2CID 2310048.
  6. ^ Janz R, Sudhof TC, Hammer RE, Unni V, Siegelbaum SA, Bolshakov VY (Jan 2000). "Essential roles in synaptic plasticity for synaptogyrin I and synaptophysin I". Neuron. 24 (3): 687–700. doi:10.1016/S0896-6273(00)81122-8. PMID 10595519.
  7. ^ a b "Entrez Gene: SYNGR1 synaptogyrin 1".

Further reading

edit