STS-1 (gene)

For 1981 American spaceflight, see STS-1.

Ubiquitin-associated and SH3 domain-containing protein B is a protein that in humans is encoded by the UBASH3B gene.

UBASH3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CPW, 2E5K
Identifiers
Aliases	UBASH3B, STS-1, STS1, TULA-2, p70, TULA2, ubiquitin associated and SH3 domain containing B
External IDs	OMIM: 609201; MGI: 1920078; HomoloGene: 13152; GeneCards: UBASH3B; OMA:UBASH3B - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q24.1 Start 122,655,722 bp End 122,814,473 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.1 Start 40,922,394 bp End 41,072,993 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pons cerebellum cerebellar cortex cerebellar hemisphere cerebellar vermis right hemisphere of cerebellum stromal cell of endometrium decidua blood spleen Top expressed in lumbar spinal ganglion trigeminal ganglion Rostral migratory stream zygote supraoptic nucleus otolith organ utricle secondary oocyte cerebellar vermis lobe of cerebellum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine phosphatase activity protein binding phosphoprotein phosphatase activity hydrolase activity identical protein binding phosphoprotein binding ubiquitin protein ligase binding phosphatase activity Cellular component cytoplasm nucleus Biological process regulation of release of sequestered calcium ion into cytosol negative regulation of signal transduction peptidyl-tyrosine dephosphorylation negative regulation of platelet aggregation regulation of osteoclast differentiation negative regulation of protein kinase activity negative regulation of osteoclast differentiation negative regulation of bone resorption platelet activation collagen-activated tyrosine kinase receptor signaling pathway collagen-activated signaling pathway platelet aggregation regulation of protein binding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84959 72828 Ensembl ENSG00000154127 ENSMUSG00000032020 UniProt Q8TF42 Q8BGG7 RefSeq (mRNA) NM_032873 NM_001363365 NM_176860 NM_001357412 RefSeq (protein) NP_116262 NP_001350294 NP_789830 NP_001344341 Location (UCSC) Chr 11: 122.66 – 122.81 Mb Chr 9: 40.92 – 41.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that contains a ubiquitin associated protein domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Kowanetz K, Crosetto N, Haglund K, et al. (2004). "Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases". J. Biol. Chem. 279 (31): 32786–95. doi:10.1074/jbc.M403759200. PMID 15159412.
• Guo F, Sigua C, Bali P, et al. (2005). "Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells". Blood. 105 (3): 1246–55. doi:10.1182/blood-2004-05-2041. PMID 15388581.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Hoeller D, Crosetto N, Blagoev B, et al. (2006). "Regulation of ubiquitin-binding proteins by monoubiquitination". Nat. Cell Biol. 8 (2): 163–9. doi:10.1038/ncb1354. PMID 16429130. S2CID 1324257.