STAU2

Double-stranded RNA-binding protein Staufen homolog 2 is a protein that in humans is encoded by the STAU2 gene.

STAU2
Identifiers
Aliases	STAU2, 39K2, 39K3, staufen double-stranded RNA binding protein 2
External IDs	OMIM: 605920 MGI: 1352508 HomoloGene: 8666 GeneCards: STAU2
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.11 Start 73,420,369 bp End 73,747,708 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 A3 Start 16,298,898 bp End 16,590,336 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence prefrontal cortex gastrocnemius muscle Brodmann area 9 cingulate gyrus endothelial cell Achilles tendon left ventricle gallbladder islet of Langerhans Top expressed in superior frontal gyrus medial vestibular nucleus piriform cortex barrel cortex Region I of hippocampus proper facial motor nucleus medial dorsal nucleus substantia nigra globus pallidus inferior colliculus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function double-stranded RNA binding protein binding RNA binding Cellular component cytoplasm microtubule nucleolus endoplasmic reticulum membrane nucleus Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27067 29819 Ensembl ENSG00000040341 ENSMUSG00000025920 UniProt Q9NUL3 Q8CJ67 RefSeq (mRNA) NM_014393 NM_001164380 NM_001164381 NM_001164382 NM_001164383 NM_001164384 NM_001164385 NM_001111272 NM_025303 NM_001347044 NM_001347045 RefSeq (protein) NP_001157852 NP_001157853 NP_001157854 NP_001157855 NP_001157856 NP_001157857 NP_055208 NP_001104742 NP_001333973 NP_001333974 NP_079579 Location (UCSC) Chr 8: 73.42 – 73.75 Mb Chr 1: 16.3 – 16.59 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Expression of Stau2 was sufficient to increase eye size, suggesting a novel biological role of Stau2 in eye morphogenesis. Acting as a HIV-1 dependency factor, Staufen-2 promotes HIV-1 proliferation by positively regulating RNA export activity of viral protein Rev and recently it was reported that Staufen-2 is incorporated into HIV-1 particles and boost viral infectivity

Further reading

• Kiebler MA, DesGroseillers L (January 2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system". Neuron. 25 (1): 19–28. doi:10.1016/S0896-6273(00)80868-5. PMID 10707969. S2CID 2565210.
• Furic L, Maher-Laporte M, DesGroseillers L (February 2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes". RNA. 14 (2): 324–35. doi:10.1261/rna.720308. PMC 2212254. PMID 18094122.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Chatel-Chaix L, Clément JF, Martel C, Bériault V, Gatignol A, DesGroseillers L, Mouland AJ (April 2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles". Molecular and Cellular Biology. 24 (7): 2637–48. doi:10.1128/MCB.24.7.2637-2648.2004. PMC 371130. PMID 15024055.
• Duchaîne TF, Hemraj I, Furic L, Deitinghoff A, Kiebler MA, DesGroseillers L (August 2002). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles". Journal of Cell Science. 115 (Pt 16): 3285–95. doi:10.1242/jcs.115.16.3285. PMID 12140260.