SRPRB

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene.

SRPRB
Identifiers
Aliases	SRPRB, APMCF1, SRP receptor beta subunit, SRP receptor subunit beta, SR-beta
External IDs	OMIM: 616883 MGI: 102964 HomoloGene: 6332 GeneCards: SRPRB
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.1 Start 133,784,023 bp End 133,825,772 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 103,065,231 bp End 103,079,336 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas parotid gland islet of Langerhans tibia stromal cell of endometrium periodontal fiber pericardium corpus epididymis kidney tubule trachea Top expressed in saccule otic placode yolk sac spermatocyte renal corpuscle external carotid artery parotid gland internal carotid artery seminal vesicula molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding signal recognition particle binding GTP binding Cellular component endoplasmic reticulum membrane cytoplasmic microtubule cytoplasm integral component of membrane signal recognition particle receptor complex intracellular anatomical structure endoplasmic reticulum membrane Biological process IRE1-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58477 20818 Ensembl ENSG00000144867 ENSMUSG00000032553 UniProt Q9Y5M8 P47758 RefSeq (mRNA) NM_021203 NM_001379313 NM_009275 RefSeq (protein) NP_067026 NP_001366242 NP_033301 Location (UCSC) Chr 3: 133.78 – 133.83 Mb Chr 9: 103.07 – 103.08 Mb PubMed search
Wikidata
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The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.

Further reading

• Bacher G, Pool M, Dobberstein B (1999). "The Ribosome Regulates the Gtpase of the β-Subunit of the Signal Recognition Particle Receptor". J. Cell Biol. 146 (4): 723–30. doi:10.1083/jcb.146.4.723. PMC 2156146. PMID 10459008.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer". World J. Gastroenterol. 9 (8): 1719–24. doi:10.3748/wjg.v9.i8.1719. PMC 4611530. PMID 12918107.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
• Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297. S2CID 1871553.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.