This article may be too technical for most readers to understand. (January 2021) |
SQ2397 is an element of RNA that was identified by RNA deep sequencing of Clostridioides difficile 630[1] where it is located immediately upstream of an uncharacterized HTH-type transcriptional regulator.
| SQ2397 | |
|---|---|
 Consensus secondary structure and sequence conservation of Cis-regulator of HTH transcription factor | |
| Identifiers | |
| Symbol | SQ2397 |
| Rfam | RF03532 |
| Other data | |
| RNA type | Cis-reg |
| GO | GO:0051090 |
| SO | SO:0005836 |
| PDB structures | PDBe |
Homologs are found widely across Bacillota, consistently located 5’ of transcriptional regulators of similar size and sequence, which strongly supports a cis-regulatory function.
This RNA is referred to as CD630_SQ2397.[1]
The sequence is highly conserved and shows no evidence for covariation as per R-scape analysis. The proposed secondary structure is therefore purely hypothetical.
References
edit- ^ a b Soutourina OA, Monot M, Boudry P, Saujet L, Pichon C, Sismeiro O; et al. (2013). "Genome-wide identification of regulatory RNAs in the human pathogen Clostridium difficile". PLOS Genet. 9 (5): e1003493. doi:10.1371/journal.pgen.1003493. PMC 3649979. PMID 23675309.
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