SPRR2A

Small proline-rich protein 2A is a protein that in humans is encoded by the SPRR2A gene.

SPRR2A
Identifiers
Aliases	SPRR2A, small proline rich protein 2A
External IDs	OMIM: 182267 HomoloGene: 130544 GeneCards: SPRR2A
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 153,056,120 bp End 153,057,512 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gums body of tongue amniotic fluid oral cavity human penis vulva superior surface of tongue palpebral conjunctiva sperm vagina n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural molecule activity Cellular component cytoplasm cornified envelope cytosol Biological process peptide cross-linking keratinization keratinocyte differentiation epidermis development cornification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6700 n/a Ensembl ENSG00000241794 n/a UniProt P35326 n/a RefSeq (mRNA) NM_005988 n/a RefSeq (protein) NP_005979 n/a Location (UCSC) Chr 1: 153.06 – 153.06 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Further reading

• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
• Tong L, Corrales RM, Chen Z, et al. (2006). "Expression and Regulation of Cornified Envelope Proteins in Human Corneal Epithelium". Invest. Ophthalmol. Vis. Sci. 47 (5): 1938–46. doi:10.1167/iovs.05-1129. PMC 2906387. PMID 16639001.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus". Mol. Cells. 17 (3): 477–84. doi:10.1016/S1016-8478(23)13069-X. PMID 15232223.
• Cabral A, Fischer DF, Vermeij WP, Backendorf C (2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation". J. Biol. Chem. 278 (20): 17792–9. doi:10.1074/jbc.M300508200. hdl:1887/50054. PMID 12624109.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
• Fischer DF, van Drunen CM, Winkler GS, et al. (1999). "Involvement of a nuclear matrix association region in the regulation of the SPRR2A keratinocyte terminal differentiation marker". Nucleic Acids Res. 26 (23): 5288–94. doi:10.1093/nar/26.23.5288. PMC 147987. PMID 9826750.
• Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope". J. Biol. Chem. 272 (3): 2021–30. doi:10.1074/jbc.272.3.2021. PMID 8999895.
• Fischer DF, Gibbs S, van De Putte P, Backendorf C (1996). "Interdependent transcription control elements regulate the expression of the SPRR2A gene during keratinocyte terminal differentiation". Mol. Cell. Biol. 16 (10): 5365–74. doi:10.1128/MCB.16.10.5365. PMC 231535. PMID 8816448.
• Gibbs S, Lohman F, Teubel W, et al. (1990). "Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes". Nucleic Acids Res. 18 (15): 4401–7. doi:10.1093/nar/18.15.4401. PMC 331257. PMID 2388825.