SIPA1

Signal-induced proliferation-associated protein 1 is a protein that in humans is encoded by the SIPA1 gene.

SIPA1
Identifiers
Aliases	SIPA1, SPA1, signal-induced proliferation-associated 1
External IDs	OMIM: 602180 MGI: 107576 HomoloGene: 7940 GeneCards: SIPA1
Gene location (Human) Chr. Chromosome 11 (human) Band 11q13.1 Start 65,638,101 bp End 65,650,918 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19 A|19 4.34 cM Start 5,701,213 bp End 5,713,735 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen upper lobe of left lung sural nerve right lung monocyte blood right lobe of liver left uterine tube lymph node right coronary artery Top expressed in yolk sac spleen thymus blood internal carotid artery external carotid artery left lung subcutaneous adipose tissue dermis adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding GTPase activator activity protein C-terminus binding Cellular component cytoplasm perinuclear region of cytoplasm cytosol transport vesicle membrane endomembrane system nucleus protein-containing complex Biological process negative regulation of cell adhesion negative regulation of cell cycle cellular response to water deprivation cell population proliferation intracellular signal transduction regulation of small GTPase mediated signal transduction cytoskeleton organization negative regulation of cell growth signal transduction positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6494 20469 Ensembl ENSG00000213445 ENSMUSG00000056917 UniProt Q96FS4 P46062 RefSeq (mRNA) NM_006747 NM_153253 NM_001164480 NM_001164481 NM_001164482 NM_001164568 NM_011379 RefSeq (protein) NP_006738 NP_694985 n/a Location (UCSC) Chr 11: 65.64 – 65.65 Mb Chr 19: 5.7 – 5.71 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.

Further reading

• Minato N (1997). "[Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]". Hum. Cell. 9 (1): 11–6. PMID 9183624.
• Hattori M, Tsukamoto N, Nur-e-Kamal MS, et al. (1995). "Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression". Mol. Cell. Biol. 15 (1): 552–60. doi:10.1128/mcb.15.1.552. PMC 232010. PMID 7799964.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kurachi H, Wada Y, Tsukamoto N, et al. (1997). "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product". J. Biol. Chem. 272 (44): 28081–8. doi:10.1074/jbc.272.44.28081. PMID 9346962. S2CID 26338837.
• Ebrahimi S, Wang E, Udar N, et al. (1998). "Genomic organization and cloning of the human homologue of murine Sipa-1". Gene. 214 (1–2): 215–21. doi:10.1016/S0378-1119(98)00212-1. PMID 9651531.
• Tsukamoto N, Hattori M, Yang H, et al. (1999). "Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion". J. Biol. Chem. 274 (26): 18463–9. doi:10.1074/jbc.274.26.18463. PMID 10373454. S2CID 46045210.
• Hoecker U, Quail PH (2001). "The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis". J. Biol. Chem. 276 (41): 38173–8. doi:10.1074/jbc.M103140200. PMID 11461903.
• Roy BC, Kohu K, Matsuura K, et al. (2003). "SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus". Genes Cells. 7 (6): 607–17. doi:10.1046/j.1365-2443.2002.00546.x. PMID 12059963. S2CID 42090467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Farina A, Hattori M, Qin J, et al. (2004). "Bromodomain Protein Brd4 Binds to GTPase-Activating SPA-1, Modulating Its Activity and Subcellular Localization". Mol. Cell. Biol. 24 (20): 9059–69. doi:10.1128/MCB.24.20.9059-9069.2004. PMC 517877. PMID 15456879.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Crawford NP, Ziogas A, Peel DJ, et al. (2006). "Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer". Breast Cancer Res. 8 (2): R16. doi:10.1186/bcr1389. PMC 1483843. PMID 16563182.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.