SF3 may refer to:
- Street Fighter III, a video game
- Shining Force 3, a video game
- Star Fox Adventures, the third game in the overall Star Fox franchise
- The Saab 340 turboprop airplane
- Syphon Filter 3, a video game
- Secret Files 3, a 2013 point-and-click adventure game
- Sulfur trifluoride, a chemical compound.