SEC61B

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.

SEC61B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WWB, 4CG6
Identifiers
Aliases	SEC61B, Sec61 translocon beta subunit, SEC61 translocon subunit beta
External IDs	OMIM: 609214 MGI: 1913462 HomoloGene: 38229 GeneCards: SEC61B
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.33 Start 99,222,064 bp End 99,230,615 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 47,474,658 bp End 47,483,242 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland body of pancreas oocyte corpus epididymis pylorus anterior pituitary trachea right lobe of liver cardia canal of the cervix Top expressed in parotid gland seminal vesicula submandibular gland islet of Langerhans molar maxillary prominence somite lacrimal gland crypt of lieberkuhn of small intestine cervix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function epidermal growth factor binding protein binding RNA binding protein-transporting ATPase activity Cellular component integral component of membrane cytosol membrane Sec61 translocon complex endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum Sec complex Biological process retrograde protein transport, ER to cytosol IRE1-mediated unfolded protein response ubiquitin-dependent ERAD pathway protein transport intracellular protein transport SRP-dependent cotranslational protein targeting to membrane, translocation posttranslational protein targeting to membrane, translocation transport regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10952 66212 Ensembl ENSG00000106803 ENSMUSG00000053317 UniProt P60468 Q9CQS8 RefSeq (mRNA) NM_006808 NM_024171 RefSeq (protein) NP_006799 NP_077133 Location (UCSC) Chr 9: 99.22 – 99.23 Mb Chr 4: 47.47 – 47.48 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Wiertz EJ, Tortorella D, Bogyo M, et al. (1997). "Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction". Nature. 384 (6608): 432–8. doi:10.1038/384432a0. PMID 8945469. S2CID 6276718.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Knight BC, High S (1998). "Membrane integration of Sec61alpha: a core component of the endoplasmic reticulum translocation complex". Biochem. J. 331 (Pt 1): 161–7. doi:10.1042/bj3310161. PMC 1219334. PMID 9512475.
• Chen Y, Le Cahérec F, Chuck SL (1998). "Calnexin and other factors that alter translocation affect the rapid binding of ubiquitin to apoB in the Sec61 complex". J. Biol. Chem. 273 (19): 11887–94. doi:10.1074/jbc.273.19.11887. PMID 9565615.
• Kalies KU, Rapoport TA, Hartmann E (1998). "The β Subunit of the Sec61 Complex Facilitates Cotranslational Protein Transport and Interacts with the Signal Peptidase during Translocation". J. Cell Biol. 141 (4): 887–94. doi:10.1083/jcb.141.4.887. PMC 2132780. PMID 9585408.
• Bebök Z, Mazzochi C, King SA, et al. (1998). "The mechanism underlying cystic fibrosis transmembrane conductance regulator transport from the endoplasmic reticulum to the proteasome includes Sec61beta and a cytosolic, deglycosylated intermediary". J. Biol. Chem. 273 (45): 29873–8. doi:10.1074/jbc.273.45.29873. PMID 9792704.
• Ingley E, Williams JH, Walker CE, et al. (1999). "A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit". FEBS Lett. 459 (1): 69–74. doi:10.1016/S0014-5793(99)01188-6. PMID 10508919. S2CID 30948975.
• Yamaguchi A, Hori O, Stern DM, et al. (2000). "Stress-Associated Endoplasmic Reticulum Protein 1 (Serp1)/Ribosome-Associated Membrane Protein 4 (Ramp4) Stabilizes Membrane Proteins during Stress and Facilitates Subsequent Glycosylation". J. Cell Biol. 147 (6): 1195–204. doi:10.1083/jcb.147.6.1195. PMC 2168098. PMID 10601334.
• Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Besemer J, Harant H, Wang S, et al. (2005). "Selective inhibition of cotranslational translocation of vascular cell adhesion molecule 1". Nature. 436 (7048): 290–3. Bibcode:2005Natur.436..290B. doi:10.1038/nature03670. PMID 16015337. S2CID 4431610.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells". J. Proteome Res. 4 (4): 1339–46. doi:10.1021/pr050048h. PMID 16083285.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Liao HJ, Carpenter G (2007). "Role of the Sec61 Translocon in EGF Receptor Trafficking to the Nucleus and Gene Expression". Mol. Biol. Cell. 18 (3): 1064–72. doi:10.1091/mbc.E06-09-0802. PMC 1805100. PMID 17215517.