Protein transport protein Sec24B is a protein that in humans is encoded by the SEC24B gene.[5][6][7]

SEC24B
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesSEC24B, SEC24, SEC24 homolog B, COPII coat complex component
External IDsOMIM: 607184; MGI: 2139764; HomoloGene: 55968; GeneCards: SEC24B; OMA:SEC24B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042734
NM_001300813
NM_006323
NM_001318085
NM_001318086

NM_207209

RefSeq (protein)

NP_001036199
NP_001287742
NP_001305014
NP_001305015
NP_006314

n/a

Location (UCSC)Chr 4: 109.43 – 109.54 MbChr 3: 129.78 – 129.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a member of the SEC24 subfamily of the SEC23/SEC24 family, which is involved in vesicle trafficking. The encoded protein has similarity to yeast Sec24p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The role of this gene product is implicated in the shaping of the vesicle, and also in cargo selection and concentration. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138802Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001052Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Apr 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J Biol Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
  6. ^ Tang BL, Kausalya J, Low DY, Lock ML, Hong W (Jun 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochem Biophys Res Commun. 258 (3): 679–84. doi:10.1006/bbrc.1999.0574. PMID 10329445.
  7. ^ a b "Entrez Gene: SEC24B SEC24 related gene family, member B (S. cerevisiae)".

Further reading

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