Ropsacitinib

Ropsacitinib
Identifiers
	IUPAC name 3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile;
CAS Number	2127109-84-4;
PubChem CID	130339268;
DrugBank	DB18709;
ChemSpider	ID78317711;
UNII	HY5SOV7O0Q;
ChEMBL	ChEMBL4459585;
Chemical and physical data
Formula	C20H17N9
Molar mass	383.419 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1C=C(C=N1)C2=CN3C(=CC=N3)C(=N2)C4=CN(N=C4)C5(CC(C5)C#N)CC#N;
	InChI InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3; Key:XPLZTJWZDBFWDE-UHFFFAOYSA-N;

Ropsacitinib (PF-06826647) is a drug which is an orally active, selective tyrosine kinase 2 (TYK2) inhibitor. It has been researched for various autoimmune inflammatory conditions, primarily plaque psoriasis.^[1]^[2]^[3]

References

^ Martin G (February 2023). "Novel Therapies in Plaque Psoriasis: A Review of Tyrosine Kinase 2 Inhibitors". Dermatology and Therapy. 13 (2): 417–435. doi:10.1007/s13555-022-00878-9. PMC 9884727. PMID 36592300.
^ Zhang K, Ye K, Tang H, Qi Z, Wang T, Mao J, et al. (April 2023). "Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors". Journal of Medicinal Chemistry. 66 (7): 4378–4416. doi:10.1021/acs.jmedchem.2c01800. PMID 36951608.
^ Morand E, Merola JF, Tanaka Y, Gladman D, Fleischmann R (April 2024). "TYK2: an emerging therapeutic target in rheumatic disease". Nature Reviews. Rheumatology. 20 (4): 232–240. doi:10.1038/s41584-024-01093-w. PMID 38467779.

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[1] Martin G (February 2023). "Novel Therapies in Plaque Psoriasis: A Review of Tyrosine Kinase 2 Inhibitors". Dermatology and Therapy. 13 (2): 417–435. doi:10.1007/s13555-022-00878-9. PMC 9884727. PMID 36592300.

[2] Zhang K, Ye K, Tang H, Qi Z, Wang T, Mao J, et al. (April 2023). "Development and Therapeutic Implications of Tyrosine Kinase 2 Inhibitors". Journal of Medicinal Chemistry. 66 (7): 4378–4416. doi:10.1021/acs.jmedchem.2c01800. PMID 36951608.

[3] Morand E, Merola JF, Tanaka Y, Gladman D, Fleischmann R (April 2024). "TYK2: an emerging therapeutic target in rheumatic disease". Nature Reviews. Rheumatology. 20 (4): 232–240. doi:10.1038/s41584-024-01093-w. PMID 38467779.

[1]

[2]

[3]

Identifiers

IUPAC name 3-(cyanomethyl)-3-[4-[6-(1-methylpyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl]pyrazol-1-yl]cyclobutane-1-carbonitrile
CAS Number	2127109-84-4
PubChem CID	130339268
DrugBank	DB18709
ChemSpider	ID78317711
UNII	HY5SOV7O0Q
ChEMBL	ChEMBL4459585
Chemical and physical data
Formula	C₂₀H₁₇N₉
Molar mass	383.419 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN1C=C(C=N1)C2=CN3C(=CC=N3)C(=N2)C4=CN(N=C4)C5(CC(C5)C#N)CC#N
InChI InChI=1S/C20H17N9/c1-27-11-15(9-24-27)17-13-28-18(2-5-23-28)19(26-17)16-10-25-29(12-16)20(3-4-21)6-14(7-20)8-22/h2,5,9-14H,3,6-7H2,1H3 Key:XPLZTJWZDBFWDE-UHFFFAOYSA-N

Ropsacitinib

See also

References