Ring finger protein 103

Ring finger protein 103 is a protein that in humans is encoded by the RNF103 gene. [5]

RNF103
Identifiers
AliasesRNF103, HKF-1, KF-1, KF1, ZFP-103, ZFP103, ring finger protein 103
External IDsOMIM: 602507; MGI: 109483; HomoloGene: 4146; GeneCards: RNF103; OMA:RNF103 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005667
NM_001198951
NM_001198952

NM_009543
NM_001308303

RefSeq (protein)

NP_001185880
NP_001185881
NP_005658

NP_001295232
NP_033569

Location (UCSC)Chr 2: 86.6 – 86.62 MbChr 6: 71.47 – 71.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The protein encoded by this gene contains a RING-H2 finger, a motif known to be involved in protein-protein and protein-DNA interactions. This gene is highly expressed in normal cerebellum, but not in the cerebral cortex. The expression of the rat counterpart in the frontal cortex and hippocampus was shown to be induced by electroconvulsive treatment (ECT) as well as chronic antidepressant treatment, suggesting that this gene may be a molecular target for ECT and antidepressants. The protein is a ubiquitin ligase that functions in the endoplasmic reticulum-associated degradation pathway. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream CHMP3 (charged multivesicular body protein 3) gene.

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000239305Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052656Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Ring finger protein 103". Retrieved 2017-07-04.

Further reading

edit
  • Scheper J, Oliva B, Villà-Freixa J, Thomson TM (2009). "Analysis of electrostatic contributions to the selectivity of interactions between RING-finger domains and ubiquitin-conjugating enzymes". Proteins. 74 (1): 92–103. doi:10.1002/prot.22120. PMID 18615712. S2CID 37900633.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.