Ribonuclease T2 (EC 3.1.27.1, acid ribonuclease, acid RNase, base-non-specific ribonuclease, Escherichia coli ribonuclease I' ribonuclease PP2, Escherichia coli ribonuclease II, non-base specific ribonuclease, nonbase-specific RNase, nonspecific RNase, ribonnuclease (non-base specific), ribonuclease (non-base specific), ribonuclease II, ribonuclease M, ribonuclease N2, ribonuclease PP3, ribonuclease U4, ribonucleate 3'-oligonucleotide hydrolase, ribonucleate nucleotido-2'-transferase (cyclizing), RNAase CL, RNase (non-base specific), RNase II, RNase M, RNase Ms, RNase T2, ) is an enzyme.[1][2][3][4] It is a type of endoribonuclease. This enzyme catalyses the following chemical reaction
| Ribonuclease T2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.27.1 | ||||||||
| CAS no. | 37278-25-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Two-stage endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates
See also
editReferences
edit- ^ García-Segura JM, Orozco MM, Fominaya JM, Gavilanes JG (July 1986). "Purification, molecular and enzymic characterization of an acid RNase from the insect Ceratitis capitata". European Journal of Biochemistry. 158 (2): 367–72. doi:10.1111/j.1432-1033.1986.tb09760.x. PMID 3732273.
- ^ Heppel LA, Davies DR (1966). "Pig liver nuclei ribonuclease". In Cantoni GL (ed.). Procedures in Nucleic Acid Research. New York: Procedures in Nucleic Acid Research. pp. 31–36.
- ^ Reddi KK, Mauser LJ (March 1965). "Studies on the formation of tobacco mosaic virus ribonucleic acid. VI. Mode of degradation of host ribonucleic acid to ribonucleosides and their conversion to ribonucleoside 5′-phosphates". Proceedings of the National Academy of Sciences of the United States of America. 53 (3): 607–13. doi:10.1073/pnas.53.3.607. PMC 336984. PMID 14338240.
- ^ Uchida T, Egami F (January 1967). "The specificity of ribonuclease T2". Journal of Biochemistry. 61 (1): 44–53. doi:10.1093/oxfordjournals.jbchem.a128519. PMID 6048969.
External links
edit- Ribonuclease+T2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
