RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RHOD.[6]

RHOD
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRHOD, ARHD, RHOHP1, RHOM, Rho, RhoD, ras homolog family member D
External IDsOMIM: 605781; MGI: 108446; HomoloGene: 22409; GeneCards: RHOD; OMA:RHOD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014578
NM_001300886

NM_007485
NM_001329989

RefSeq (protein)

NP_001287815
NP_055393

NP_001316918
NP_031511

Location (UCSC)Chr 11: 67.06 – 67.07 MbChr 19: 4.48 – 4.49 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton.[6][7]

Interactions

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RhoD has been shown to interact with CNKSR1[8] and DIAPH2.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173156Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041845Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–529. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  6. ^ a b "Entrez Gene: RHOD ras homolog gene family, member D".
  7. ^ Nehru V, Voytyuk O, Lennartsson J, Aspenström P (December 2013). "RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor". Traffic. 14 (12): 1242–1254. doi:10.1111/tra.12121. PMID 24102721. S2CID 3416403.
  8. ^ Jaffe AB, Aspenström P, Hall A (February 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways". Molecular and Cellular Biology. 24 (4): 1736–1746. doi:10.1128/MCB.24.4.1736-1746.2004. PMC 344169. PMID 14749388.
  9. ^ Gasman S, Kalaidzidis Y, Zerial M (March 2003). "RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase". Nature Cell Biology. 5 (3): 195–204. doi:10.1038/ncb935. PMID 12577064. S2CID 17891748.

Further reading

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