RRAGA

RRAGA
Identifiers
Aliases	RRAGA, FIP-1, FIP1, RAGA, Ras related GTP binding A
External IDs	OMIM: 612194 MGI: 1915691 HomoloGene: 68522 GeneCards: RRAGA
Gene location (Human)
Chr.	Chromosome 9 (human)
End	19,051,025 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	86,495,522 bp
RNA expression pattern
	Top expressed in
	frontal pole; ; Brodmann area 10; ; middle frontal gyrus; ; cerebellar vermis; ; islet of Langerhans; ; smooth muscle tissue; ; Brodmann area 9; ; Brodmann area 46; ; middle temporal gyrus; ; hypothalamus;
	Top expressed in
	secondary oocyte; ; dorsomedial hypothalamic nucleus; ; visual cortex; ; superior frontal gyrus; ; lateral hypothalamus; ; paraventricular nucleus of hypothalamus; ; mammillary body; ; cerebellar cortex; ; habenula; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein homodimerization activity; GTP binding; phosphoprotein binding; protein binding; GTPase activity; ubiquitin protein ligase binding; protein heterodimerization activity;
Cellular component	cytoplasm; cytosol; GATOR1 complex; lysosomal membrane; lysosome; nucleus; Gtr1-Gtr2 GTPase complex;
Biological process	cellular response to amino acid starvation; cell death; positive regulation of cytolysis; positive regulation of TORC1 signaling; modulation by virus of host process; cellular response to amino acid stimulus; viral process; negative regulation of autophagy; positive regulation of TOR signaling; apoptotic process; protein ubiquitination; regulation of macroautophagy; cellular response to starvation; regulation of autophagy;
	Sources:Amigo / QuickGO
Orthologs
	10670
	68441
	ENSG00000155876
	ENSMUSG00000070934
	Q7L523
	Q80X95
	NM_006570
	NM_178376
	NP_006561
	NP_848463
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-related GTP-binding protein A is a protein that in humans is encoded by the RRAGA gene.^[5]^[6]^[7]

Interactions edit

RRAGA has been shown to interact with NOL8^[8] and RRAGC.^[9]^[10]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000155876 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070934 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.
^ Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC 191215. PMID 8995684.
^ "Entrez Gene: RRAGA Ras-related GTP binding A".
^ Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
^ Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

Further reading edit

Hirose E, Nakashima N, Sekiguchi T, Nishimoto T (Jan 1998). "RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway". Journal of Cell Science. 111 ( Pt 1) (1): 11–21. doi:10.1242/jcs.111.1.11. PMID 9394008.
Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000155876 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000070934 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7499430-5] Schürmann A, Brauers A, Massmann S, Becker W, Joost HG (Dec 1995). "Cloning of a novel family of mammalian GTP-binding proteins (raga d, RagBs, RagB1) with remote similarity to the Ras-related GTPases". The Journal of Biological Chemistry. 270 (48): 28982–8. doi:10.1074/jbc.270.48.28982. PMID 7499430.

[pmid8995684-6] Li Y, Kang J, Horwitz MS (Feb 1997). "Interaction of an adenovirus 14.7-kilodalton protein inhibitor of tumor necrosis factor alpha cytolysis with a new member of the GTPase superfamily of signal transducers". Journal of Virology. 71 (2): 1576–82. doi:10.1128/JVI.71.2.1576-1582.1997. PMC 191215. PMID 8995684.

[entrez-7] "Entrez Gene: RRAGA Ras-related GTP binding A".

[pmid14660641-8] Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.

[pmid16189514-9] Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

[pmid11073942-10] Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.

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