E3 ubiquitin-protein ligase Arkadia is an enzyme that in humans is encoded by the RNF111 gene.[5][6]

RNF111
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRNF111, ARK, ring finger protein 111, hRNF111
External IDsOMIM: 605840; MGI: 1934919; HomoloGene: 9741; GeneCards: RNF111; OMA:RNF111 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270528
NM_001270529
NM_001270530
NM_017610
NM_001330331

NM_033604
NM_001357494
NM_001374753

RefSeq (protein)

NP_001257457
NP_001257458
NP_001257459
NP_001317260
NP_060080

NP_291082
NP_001344423
NP_001361682

Location (UCSC)Chr 15: 58.87 – 59.1 MbChr 9: 70.33 – 70.41 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

edit

The protein encoded by this gene contains a RING finger domain, a motif known to be involved in protein-protein and protein-DNA interactions. The mouse counterpart of this gene (Rnf111/arkadia) has been shown to genetically interact with the transforming growth factor (TGF) beta-like factor Nodal, and act as a modulator of the nodal signaling cascade, which is essential for the induction of mesoderm during embryonic development.[6]

Interactions

edit

RNF111 has been shown to interact with Mothers against decapentaplegic homolog 7[7] and Mothers against decapentaplegic homolog 3.[7][8]

References

edit
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157450Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032217Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Episkopou V, Arkell R, Timmons PM, Walsh JJ, Andrew RL, Swan D (Apr 2001). "Induction of the mammalian node requires Arkadia function in the extraembryonic lineages". Nature. 410 (6830): 825–30. Bibcode:2001Natur.410..825E. doi:10.1038/35071095. PMID 11298452. S2CID 38456861.
  6. ^ a b "Entrez Gene: RNF111 ring finger protein 111".
  7. ^ a b Koinuma D, Shinozaki M, Komuro A, Goto K, Saitoh M, Hanyu A, Ebina M, Nukiwa T, Miyazawa K, Imamura T, Miyazono K (Dec 2003). "Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7". The EMBO Journal. 22 (24): 6458–70. doi:10.1093/emboj/cdg632. PMC 291827. PMID 14657019.
  8. ^ Yuzawa H, Koinuma D, Maeda S, Yamamoto K, Miyazawa K, Imamura T (Jan 2009). "Arkadia represses the expression of myoblast differentiation markers through degradation of Ski and the Ski-bound Smad complex in C2C12 myoblasts". Bone. 44 (1): 53–60. doi:10.1016/j.bone.2008.09.013. PMID 18950738.

Further reading

edit