Rhabdomyosarcoma 2 associated transcript (RMST) is a long non-coding RNA. In humans, it is located on chromosome 12q21. It is expressed at higher levels in alveolar rhabdomyosarcoma than in embryonal rhabdomyosarcoma.[3] In the brain, RMST is expressed in the developing ventral midbrain where dopaminergic neurons are formed, the developing isthmus and in the dorsal midline cells of the rostral neural tube.[4] In the midbrain-hindbrain boundary region, its expression is regulated by PAX2.[5]

RMST
Identifiers
AliasesRMST, LINC00054, NCRMS, NCRNA00054, rhabdomyosarcoma 2 associated transcript (non-protein coding), rhabdomyosarcoma 2 associated transcript
External IDsOMIM: 607045; GeneCards: RMST; OMA:RMST - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)Chr 12: 97.43 – 97.6 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255794Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Chan AS, Thorner PS, Squire JA, Zielenska M (May 2002). "Identification of a novel gene NCRMS on chromosome 12q21 with differential expression between rhabdomyosarcoma subtypes". Oncogene. 21 (19): 3029–3037. doi:10.1038/sj.onc.1205460. PMID 12082533.
  4. ^ Uhde CW, Vives J, Jaeger I, Li M (2010). "Rmst is a novel marker for the mouse ventral mesencephalic floor plate and the anterior dorsal midline cells". PLOS ONE. 5 (1): e8641. Bibcode:2010PLoSO...5.8641U. doi:10.1371/journal.pone.0008641. PMC 2799666. PMID 20062813.
  5. ^ Bouchard M, Grote D, Craven SE, Sun Q, Steinlein P, Busslinger M (June 2005). "Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region". Development. 132 (11): 2633–2643. doi:10.1242/dev.01833. PMID 15872005.

Further reading

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