RHBG

Rh family, B glycoprotein, also known as RHBG, is an ammonia transporter protein which in humans is encoded by the RHBG gene.

RHBG
Identifiers
Aliases	RHBG, SLC42A2, Rh family B glycoprotein (gene/pseudogene), Rh family B glycoprotein
External IDs	OMIM: 607079; MGI: 1927379; HomoloGene: 9469; GeneCards: RHBG; OMA:RHBG - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q22 Start 156,369,211 bp End 156,385,219 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F1|3 38.78 cM Start 88,150,181 bp End 88,162,016 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum human kidney left ovary renal medulla right lobe of liver right ovary skin of leg testicle Top expressed in right kidney inner renal medulla collecting duct of renal tubule cortical collecting duct lip human kidney glans of clitoris esophagus connecting tubule embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ankyrin binding ammonium transmembrane transporter activity Cellular component spectrin-associated cytoskeleton integral component of membrane anchored component of plasma membrane integral component of plasma membrane cytoplasmic vesicle membrane membrane cytoplasmic vesicle plasma membrane basolateral plasma membrane Biological process ammonium transmembrane transport organic cation transport transepithelial ammonium transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57127 58176 Ensembl ENSG00000132677 ENSMUSG00000104445 UniProt Q9H310 Q8BUX5 RefSeq (mRNA) NM_001256395 NM_001256396 NM_020407 NM_021375 RefSeq (protein) NP_001243324 NP_001243325 NP_065140 NP_067350 Location (UCSC) Chr 1: 156.37 – 156.39 Mb Chr 3: 88.15 – 88.16 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

RHBG and RHCG are non-erythroid members of the Rhesus (Rh) protein family that are mainly expressed in the kidney and belong to the methylammonium-ammonium permease/ammonia transporters superfamily. Rh family proteins are all predicted to be transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.

Further reading

• Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues". Blood Cells Mol. Dis. 27 (1): 90–101. doi:10.1006/bcmd.2000.0355. PMID 11358367.
• Liu Z, Chen Y, Mo R, et al. (2000). "Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis". J. Biol. Chem. 275 (33): 25641–51. doi:10.1074/jbc.M003353200. PMID 10852913.
• Liu Z, Peng J, Mo R, et al. (2001). "Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals". J. Biol. Chem. 276 (2): 1424–33. doi:10.1074/jbc.M007528200. PMID 11024028.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Ludewig U (2005). "Electroneutral ammonium transport by basolateral rhesus B glycoprotein". J. Physiol. 559 (Pt 3): 751–9. doi:10.1113/jphysiol.2004.067728. PMC 1665183. PMID 15284342.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lopez C, Métral S, Eladari D, et al. (2005). "The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells". J. Biol. Chem. 280 (9): 8221–8. doi:10.1074/jbc.M413351200. PMID 15611082.
• Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006). "Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells". Biochem. J. 391 (Pt 1): 33–40. doi:10.1042/BJ20050657. PMC 1237136. PMID 15929723.
• Huang CH, Peng J (2005). "Evolutionary conservation and diversification of Rh family genes and proteins". Proc. Natl. Acad. Sci. U.S.A. 102 (43): 15512–7. Bibcode:2005PNAS..10215512H. doi:10.1073/pnas.0507886102. PMC 1266151. PMID 16227429.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.