RANBP2-like and GRIP domain-containing protein 5 is a protein that in humans is encoded by the RGPD5 gene.[5][6][7]

RGPD5
Identifiers
AliasesRGPD5, BS-63, BS63, HEL161, RGP5, RANBP2-like and GRIP domain containing 5, RANBP2 like and GRIP domain containing 5
External IDsOMIM: 612708; MGI: 894323; HomoloGene: 87808; GeneCards: RGPD5; OMA:RGPD5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005054
NM_032260

NM_011240

RefSeq (protein)

NP_005045
NP_115636

NP_035370

Location (UCSC)Chr 2: 109.79 – 109.86 MbChr 10: 58.28 – 58.33 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene shares a high degree of sequence identity with RANBP2, a large RAN-binding protein localized at the cytoplasmic side of the nuclear pore complex. It is believed that this RANBP2 gene family member arose from a duplication event 3 Mb distal to RANBP2. Alternative splicing has been observed for this locus and two variants are described. Additional splicing is suggested but complete sequence for further transcripts has not been determined.[7]

Interactions

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RGPD5 has been shown to interact with Transportin 1.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000015568Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003226Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ciccarelli FD, von Mering C, Suyama M, Harrington ED, Izaurralde E, Bork P (March 2005). "Complex genomic rearrangements lead to novel primate gene function". Genome Research. 15 (3): 343–51. doi:10.1101/gr.3266405. PMC 551560. PMID 15710750.
  6. ^ Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, et al. (April 2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
  7. ^ a b "Entrez Gene: RGPD5 RANBP2-like and GRIP domain containing 5".
  8. ^ Cai Y, Miao SY, Wang LF (October 2001). "[Determination of the binding site of testis-specific nucleoporin BS-63 to transportin (karopherin beta 2) and the proof of their combination in vitro]". Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae. 23 (5): 462–6. PMID 12905863.

Further reading

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