RCC1 and BTB domain-containing protein 1 is a protein that in humans is encoded by the RCBTB1 gene.[4][5]

RCBTB1
Identifiers
AliasesRCBTB1, CLLD7, CLLL7, GLP, RCC1 and BTB domain containing protein 1, RDEOA
External IDsOMIM: 607867; MGI: 1918580; HomoloGene: 10061; GeneCards: RCBTB1; OMA:RCBTB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018191

NM_027764
NM_001360610
NM_001360611

RefSeq (protein)

NP_082040
NP_001347539
NP_001347540

Location (UCSC)n/aChr 14: 59.44 – 59.47 Mb
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rats, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. The C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.[5]

References

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  1. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035469Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Mabuchi H, Fujii H, Calin G, Alder H, Negrini M, Rassenti L, Kipps TJ, Bullrich F, Croce CM (Apr 2001). "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia". Cancer Res. 61 (7): 2870–7. PMID 11306461.
  5. ^ a b "Entrez Gene: RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1".

Further reading

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