RBPJ

RBPJ
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2F8X, 3NBN, 3V79
Identifiers
Aliases	RBPJ, AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombination signal binding protein for immunoglobulin kappa J region, RBP-J kappa, RBP-JK, CBF-1
External IDs	OMIM: 147183; MGI: 96522; HomoloGene: 7511; GeneCards: RBPJ; OMA:RBPJ - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	26,435,131 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	53,814,704 bp
RNA expression pattern
	Top expressed in
	inferior olivary nucleus; ; Achilles tendon; ; nipple; ; corpus callosum; ; dorsal motor nucleus of vagus nerve; ; middle temporal gyrus; ; synovial joint; ; inferior ganglion of vagus nerve; ; pericardium; ; visceral pleura;
	Top expressed in
	vestibular membrane of cochlear duct; ; stroma of bone marrow; ; ventricular zone; ; zygote; ; renal corpuscle; ; carotid body; ; ciliary body; ; Paneth cell; ; medial ganglionic eminence; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein N-terminus binding; protein binding; DNA strand exchange activity; chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA binding; transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding; DNA-binding transcription factor activity; sequence-specific DNA binding; transcription factor binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleolus; MAML1-RBP-Jkappa- ICN1 complex; transcription regulator complex; cytoplasm; nucleus; nucleoplasm; transcription repressor complex;
Biological process	artery morphogenesis; regulation of transcription by RNA polymerase II; neuron differentiation; epidermal cell fate specification; positive regulation of cell population proliferation; club cell differentiation; somatic stem cell population maintenance; endocardium development; cell fate commitment; DNA recombination; somitogenesis; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia; defense response to bacterium; regulation of timing of cell differentiation; regulation of transcription, DNA-templated; humoral immune response; keratinocyte differentiation; hair follicle maturation; negative regulation of cell population proliferation; pituitary gland development; negative regulation of cell differentiation; Notch signaling involved in heart development; transcription, DNA-templated; positive regulation of gene expression; arterial endothelial cell fate commitment; myeloid dendritic cell differentiation; blood vessel remodeling; secondary heart field specification; regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter; sebaceous gland development; positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; inflammatory response to antigenic stimulus; heart development; auditory receptor cell fate commitment; B cell differentiation; regulation of gene expression; Notch signaling pathway; dorsal aorta morphogenesis; atrioventricular canal development; positive regulation of ephrin receptor signaling pathway; epithelial to mesenchymal transition involved in endocardial cushion formation; outflow tract morphogenesis; cardiac left ventricle morphogenesis; negative regulation of transcription by RNA polymerase II; labyrinthine layer blood vessel development; blood vessel lumenization; endocardium morphogenesis; ventricular trabecula myocardium morphogenesis; negative regulation of ossification; positive regulation of cell proliferation involved in heart morphogenesis; positive regulation of cardiac muscle cell proliferation; angiogenesis; epithelial to mesenchymal transition; positive regulation of BMP signaling pathway; positive regulation of ERBB signaling pathway; blood vessel endothelial cell fate specification; negative regulation of transcription, DNA-templated; positive regulation of transcription of Notch receptor target; positive regulation of Notch signaling pathway; hemopoiesis; aortic valve development; pulmonary valve development; ventricular septum morphogenesis; negative regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3516
	19664
	ENSG00000168214
	ENSMUSG00000039191
	Q06330
	P31266
NM_005349; NM_015874; NM_203283; NM_203284; NM_001363577;
	NM_001374400; NM_001374401; NM_001374402; NM_001374403; NM_001379406; NM_001379407; NM_001379408; NM_001379409
	NM_001080927; NM_001080928; NM_001277116; NM_009035; NM_001359152
NP_005340; NP_056958; NP_976028; NP_976029; NP_001350506;
	NP_001361329; NP_001361330; NP_001361331; NP_001361332; NP_001366335; NP_001366336; NP_001366337; NP_001366338
	NP_001074396; NP_001074397; NP_001264045; NP_033061; NP_001346081
	Wikidata
View/Edit Human	View/Edit Mouse

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.^[5]^[6]^[7]

RBPJ^[8] also known as CBF1, is the human homolog for the Drosophila gene Suppressor of Hairless. Its promoter region is classically used to demonstrate Notch1 signaling.^[9]

Interactions

RBPJ has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000039191 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Amakawa R, Jing W, Ozawa K, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–315. doi:10.1006/geno.1993.1326. PMID 8406481.
^ Tang X, Saito-Ohara F, Song J, et al. (June 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–341. doi:10.1007/BF02766956. PMID 9290259.
^ "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".
^ "HGNC: RBPJ Symbol Report".
^ Hsieh JJ, Henkel T, Salmon P, et al. (March 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–959. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.
^ Nam Y, Weng AP, Aster JC, et al. (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–21239. doi:10.1074/jbc.M301567200. PMID 12644465.
^ Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.
^ Beatus P, Lundkvist J, Oberg C, et al. (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.
^ Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.
^ Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.
^ ^a ^b Zhou S, Fujimuro M, Hsieh JJ, et al. (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–1947. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
^ Hsieh JJ, Zhou S, Chen L, et al. (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.
^ Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
^ Overman J, Fontaine F, Wylie-Sears J, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.). "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife. 8: e43026. doi:10.7554/eLife.43026. PMC 6667216. PMID 31358114.
^ Díaz-Trelles R, Scimia MC, Bushway P, et al. (June 2016). "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications. 7 (1): 12088. Bibcode:2016NatCo...712088D. doi:10.1038/ncomms12088. PMC 4931341. PMID 27357444.

External links

RBPJ+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168214 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000039191 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8406481-5] Amakawa R, Jing W, Ozawa K, et al. (August 1993). "Human Jk recombination signal binding protein gene (IGKJRB): comparison with its mouse homologue". Genomics. 17 (2): 306–315. doi:10.1006/geno.1993.1326. PMID 8406481.

[pmid9290259-6] Tang X, Saito-Ohara F, Song J, et al. (June 1997). "Assignment of the human gene for KBF2/RBP-Jk to chromosome 9p12-13 and 9q13 by fluorescence in situ hybridization". The Japanese Journal of Human Genetics. 42 (2): 337–341. doi:10.1007/BF02766956. PMID 9290259.

[entrez-7] "NCBI Gene: RBPJ recombination signal binding protein for immunoglobulin kappa J region".

[HGNC_RBPJ-8] "HGNC: RBPJ Symbol Report".

[MCB-9] Hsieh JJ, Henkel T, Salmon P, et al. (March 1996). "Truncated mammalian Notch1 activates CBF1/RBPJk-repressed genes by a mechanism resembling that of Epstein-Barr virus EBNA2". Molecular and Cellular Biology. 16 (3): 952–959. doi:10.1128/mcb.16.3.952. PMC 231077. PMID 8622698.

[pmid12644465-10] Nam Y, Weng AP, Aster JC, et al. (June 2003). "Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex". The Journal of Biological Chemistry. 278 (23): 21232–21239. doi:10.1074/jbc.M301567200. PMID 12644465.

[pmid9111040-11] Aster JC, Robertson ES, Hasserjian RP, et al. (April 1997). "Oncogenic forms of NOTCH1 lacking either the primary binding site for RBP-Jkappa or nuclear localization sequences retain the ability to associate with RBP-Jkappa and activate transcription". The Journal of Biological Chemistry. 272 (17): 11336–11343. doi:10.1074/jbc.272.17.11336. PMID 9111040.

[pmid11404076-12] Beatus P, Lundkvist J, Oberg C, et al. (June 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076. S2CID 9526831.

[pmid11509665-13] Zhou S, Hayward SD (September 2001). "Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex". Molecular and Cellular Biology. 21 (18): 6222–6232. doi:10.1128/mcb.21.18.6222-6232.2001. PMC 87339. PMID 11509665.

[pmid10747963-14] Kurooka H, Honjo T (June 2000). "Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5". The Journal of Biological Chemistry. 275 (22): 17211–17220. doi:10.1074/jbc.M000909200. PMID 10747963.

[pmid10644367-15] Zhou S, Fujimuro M, Hsieh JJ, et al. (February 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–1947. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.

[pmid9874765-16] Hsieh JJ, Zhou S, Chen L, et al. (January 1999). "CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex". Proceedings of the National Academy of Sciences of the United States of America. 96 (1): 23–28. Bibcode:1999PNAS...96...23H. doi:10.1073/pnas.96.1.23. PMC 15086. PMID 9874765.

[pmid10713164-17] Zhou S, Fujimuro M, Hsieh JJ, et al. (April 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–2410. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.

[18] Overman J, Fontaine F, Wylie-Sears J, et al. (July 2019). van Lohuizen M, Koh GY, Ostergaard P (eds.). "R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma". eLife. 8: e43026. doi:10.7554/eLife.43026. PMC 6667216. PMID 31358114.

[19] Díaz-Trelles R, Scimia MC, Bushway P, et al. (June 2016). "Notch-independent RBPJ controls angiogenesis in the adult heart". Nature Communications. 7 (1): 12088. Bibcode:2016NatCo...712088D. doi:10.1038/ncomms12088. PMC 4931341. PMID 27357444.

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RBPJ

Contents

Interactions

References

Further reading

External links