Purmorphamine was the first small-molecule agonist developed for the protein Smoothened, a key part of the hedgehog signaling pathway, which is involved in bone growth, cardiovascular regeneration and brain development as well as having a number of other functions in the body. Purmorphamine has been shown to induce osteogenesis in bone tissue as well as influencing growth and differentiation of neurons in the brain.[1][2][3][4][5][6] [7]
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Formula | C31H32N6O2 |
Molar mass | 520.637 g·mol−1 |
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References
edit- ^ Wu X, Ding S, Ding Q, Gray NS, Schultz PG (December 2002). "A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells". Journal of the American Chemical Society. 124 (49): 14520–1. doi:10.1021/ja0283908. PMID 12465946.
- ^ Wu X, Walker J, Zhang J, Ding S, Schultz PG (September 2004). "Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway". Chemistry & Biology. 11 (9): 1229–38. doi:10.1016/j.chembiol.2004.06.010. PMID 15380183.
- ^ Sinha S, Chen JK (January 2006). "Purmorphamine activates the Hedgehog pathway by targeting Smoothened". Nature Chemical Biology. 2 (1): 29–30. doi:10.1038/nchembio753. PMID 16408088. S2CID 29035911.
- ^ Lee SJ, Lee HK, Cho SY, Choi JK, Shin HK, Kwak EJ, et al. (October 2008). "Identification of osteogenic purmorphamine derivatives". Molecules and Cells. 26 (4): 380–6. PMID 18695357.
- ^ Stanton BZ, Peng LF (January 2010). "Small-molecule modulators of the Sonic Hedgehog signaling pathway". Molecular BioSystems. 6 (1): 44–54. doi:10.1039/b910196a. PMID 20024066.
- ^ Aravamudhan A, Ramos DM, Nip J, Subramanian A, James R, Harmon MD, et al. (2013). "Osteoinductive small molecules: growth factor alternatives for bone tissue engineering". Current Pharmaceutical Design. 19 (19): 3420–8. doi:10.2174/1381612811319190008. PMID 23432678.
- ^ Sharma S, Kaur A, Sharma S (April 2018). "Preconditioning potential of purmorphamine: a hedgehog activator against ischaemic reperfusion injury in ovariectomised rat heart". Perfusion. 33 (3): 209–218. doi:10.1177/0267659117732401. PMID 29065787. S2CID 3978923.