In enzymology, a prephenate dehydrogenase (NADP+) (EC 1.3.1.13) is an enzyme that catalyzes the chemical reaction
prephenate dehydrogenase (NADP+) | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.1.13 | ||||||||
CAS no. | 37251-11-9 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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- prephenate + NADP+ 4-hydroxyphenylpyruvate + CO2 + NADPH
Thus, the two substrates of this enzyme are prephenate and NADP+, whereas its 3 products are 4-hydroxyphenylpyruvate, CO2, and NADPH.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is prephenate:NADP+ oxidoreductase (decarboxylating). Other names in common use include prephenate dehydrogenase, prephenate (nicotinamide adenine dinucleotide phosphate), dehydrogenase, and prephenate dehydrogenase (NADP). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.
References edit
- Gamborg OL, Keeley FW (1966). "Aromatic metabolism in plants. I. A study of the prephenate dehydrogenase from bean plants". Biochim. Biophys. Acta. 115 (1): 65–72. doi:10.1016/0304-4165(66)90049-3. PMID 4379953.