Pregnenolone sulfate

Pregnenolone sulfate
Names
	IUPAC name 20-Oxopregn-5-en-3β-yl hydrogen sulfate
	Systematic IUPAC name (1S,3aS,3bS,7S,9aR,9bS,11aS)-1-Acetyl-9a,11a-dimethyl-2,3,3a,3b,4,6,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate
	Other names Pregn-sulf; Pregnenolone monosulfate; Pregnenolone hydrogen sulfate; Pregnenolone 3β-sulfate; 5-Pregnen-3β-ol-20-one sulfate; (3β)-3-(Sulfooxy)pregn-5-en-20-one; 5-Pregnen-3β-sulfate-20-one; 20-Oxo-5-pregnen-3β-yl sulfate
Identifiers
CAS Number	1247-64-9 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL141573 ;
ChemSpider	94802 ;
IUPHAR/BPS	4290;
PubChem CID	105074;
UNII	04Y4D91RG0 ;
CompTox Dashboard (EPA)	DTXSID60924910 ;
	InChI InChI=1S/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 Key: DIJBBUIOWGGQOP-QGVNFLHTSA-N ; InChI=1/C21H32O5S/c1-13(22)17-6-7-18-16-5-4-14-12-15(26-27(23,24)25)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19H,5-12H2,1-3H3,(H,23,24,25)/t15-,16-,17+,18-,19-,20-,21+/m0/s1 Key: DIJBBUIOWGGQOP-QGVNFLHTBX;
	SMILES CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OS(=O)(=O)O)C)C;
Properties
Chemical formula	C21H32O5S
Molar mass	396.54 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Pregnenolone sulfate (PS, PREGS) is an endogenous excitatory neurosteroid that is synthesized from pregnenolone.^[1]^[2] It is known to have cognitive and memory-enhancing, antidepressant, anxiogenic, and proconvulsant effects.^[2]

Biological activity edit

Pregnenolone sulfate is a neurosteroid with excitatory effects in the brain, acting as a potent negative allosteric modulator of the GABA_A receptor and a weak positive allosteric modulator of the NMDA receptor.^[1]^[2] To a lesser extent, it also acts as a negative allosteric modulator of the AMPA, kainate, and glycine receptors,^[3]^[4] and may interact with the nACh receptors as well.^[1] In addition to its effects on ligand-gated ion channels, pregnenolone sulfate is an agonist of the sigma receptor,^[2] as well as an activator of the TRPM1 and TRPM3 channels.^[1] It may also interact with potassium channels and voltage-gated sodium channels^[1] and has been found to inhibit voltage-gated calcium channels.^[5]

Steroidogenesis, with pregnenolone, the precursor of pregnenolone sulfate, at top left.

Pregnenolone sulfate, also known as pregn-5-en-3β-ol-20-one 3β-sulfate, is a naturally occurring pregnane steroid and a derivative of cholesterol. It is the C3β sulfate ester of pregnenolone. A closely related steroid is dehydroepiandrosterone sulfate (DHEA-S), which is the C3β sulfate ester of dehydroepiandrosterone (DHEA).

^ ^a ^b ^c ^d ^e Harteneck C (2013). "Pregnenolone sulfate: from steroid metabolite to TRP channel ligand". Molecules. 18 (10): 12012–28. doi:10.3390/molecules181012012. PMC 6270300. PMID 24084011.
^ ^a ^b ^c ^d Reddy DS (2010). "Neurosteroids: endogenous role in the human brain and therapeutic potentials". Prog. Brain Res. 186: 113–37. doi:10.1016/B978-0-444-53630-3.00008-7. PMC 3139029. PMID 21094889.
^ Park-Chung M, Wu FS, Farb DH (July 1994). "3 alpha-Hydroxy-5 beta-pregnan-20-one sulfate: a negative modulator of the NMDA-induced current in cultured neurons". Mol. Pharmacol. 46 (1): 146–50. PMID 7520124.
^ Yaghoubi N, Malayev A, Russek SJ, Gibbs TT, Farb DH (August 1998). "Neurosteroid modulation of recombinant ionotropic glutamate receptors". Brain Res. 803 (1–2): 153–60. doi:10.1016/s0006-8993(98)00644-1. PMID 9729352.
^ Mellon SH (2007). "Neurosteroid regulation of central nervous system development". Pharmacol. Ther. 116 (1): 107–24. doi:10.1016/j.pharmthera.2007.04.011. PMC 2386997. PMID 17651807.