PreQ1-II riboswitches form a class of riboswitches that specifically bind pre-queuosine1 (PreQ1), a precursor of the modified nucleoside queuosine.[1] They are found in certain species of Streptococcus and Lactococcus, and were originally identified as a conserved RNA secondary structure called the "COG4708 motif".[2] All known members of this riboswitch class appear to control members of COG4708 genes. These genes are predicted to encode membrane-bound proteins and have been proposed to be a transporter of preQ1, or a related metabolite, based on their association with preQ1-binding riboswitches.[1] PreQ1-II riboswitches have no apparent similarities in sequence or structure to preQ1-I riboswitches, a previously discovered class of preQ1-binding riboswitches. PreQ1 thus joins S-adenosylmethionine as the second metabolite to be found that is the ligand of more than one riboswitch class.

preQ1-II (pre queuosine) riboswitch
Predicted secondary structure and sequence conservation of preQ1-II
Identifiers
SymbolpreQ1-II
Alt. SymbolsCOG4708
RfamRF01054
Other data
RNA typeCis-reg; riboswitch
Domain(s)Bacteria
SOSO:0005836
PDB structuresPDBe
Consensus secondary structure of PreQ1-II riboswitches. Layout is similar to that used in previously published depictions.[2][1]

References

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  1. ^ a b c Meyer MM, Roth A, Chervin SM, Garcia GA, Breaker RR (2008). "Confirmation of a second natural preQ1 aptamer class in Streptococcaceae bacteria". RNA. 14 (4): 685–695. doi:10.1261/rna.937308. PMC 2271366. PMID 18305186.
  2. ^ a b Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.
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