Portnoff is a surname, a spelling variant of Portnov. Notable people with the surname include:

  • Leo Portnoff (1875–1940), Ukrainian musician, teacher, and composer
  • Mischa Portnoff (1901–1979), German-born American composer and teacher
  • Morrie Portnoff, Canadian astronomer, the namesake of 10333 Portnoff, main-belt asteroid

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