Boston is the capital and largest city of the Commonwealth of Massachusetts in the United States. The largest city in New England, Boston is considered the economic and cultural center of the entire New England region. The city, which had an estimated population of 596,763 in 2006, lies at the center of the Cambridge–Boston-Quincy metropolitan area—the 11th-largest metropolitan area (5th largest CSA) in the U.S., with a population of 4.4 million.
In 1630, Puritan colonists from England founded the city on the Shawmut Peninsula. During the American Revolution the Boston Massacre, the Boston Tea Party, the Battle of Bunker Hill and the Siege of Boston all occurred within the city and surrounding areas. After American independence was attained Boston became a major shipping port and manufacturing center, and its rich history now attracts 16.3 million visitors annually. The city was the site of America's first public school, Boston Latin School (1635), and first college, Harvard College (1636), in neighboring Cambridge. Boston was also home to the first subway system in the United States.
Through land reclamation and municipal annexation, Boston has expanded beyond the peninsula. With many colleges and universities within the city and surrounding area, Boston is a center of higher education and a center for health care. The city's economy is also based on research, finance, and technology — principally biotechnology.